![]() Progressive MS develops over time as a result of a failure to repair myelin. Myelin is a fatty layer of insulation covering cells and is responsible for rapid communication between nerve cells. Over time, the immune system’s sustained attack damages nerve cells’ protective myelin shells and produces lesions. Several ongoing clinical studies, including the RAM-MS, BEAT-MS, and StarMS trials, hope to shine a light on how HSCT stacks up against available therapies. Thus, clinicians currently only offer HSCT to individuals with active MS where available treatments have failed. While this may be acceptable in the face of deadly cancers, it is a big risk for people with a disease like MS. Crucially, the intense immune suppression inherent to the procedure is associated with a three to five percent mortality rate (2). Most studies of HSCTs are observational cohort studies, and the dearth of clinical studies that directly compare HSCT with other approved therapies hinders understanding of the benefits of the procedure. Evidence suggests that HSCT is most effective for the niche of patients early in their disease course when the immune system is most active, such as in the case of relapsing-remitting MS (RRMS) (2). The removal of the destructive immune cells paves the way for a new and improved immune repertoire, including naïve T cells, which help suppress inflammatory disease activity. Indeed, there is evidence that following the elimination of adaptive and innate immune cells, HSCs progressively rebuild the immune system (1). The rationale behind HSCT for MS is that it provides a tune-up by wiping out the faulty immune system and starting anew. Researchers think that a failure in the braking system of proinflammatory pathways leads to brain inflammation. In MS, the immune system mistakenly attacks nerve cells in the brain. Now, scientists are investigating HSCT for treating MS. Researchers originally developed a procedure called HSC transplantation (HSCT), which involves harvesting HSCs from a patient’s bone marrow followed by intense immune cell depletion and HSC reintroduction, to treat blood cancers. Hematopoietic stem cells (HSC) originate from bone marrow to replenish blood cells. “Stem cell” is a catchall term for any cell that can differentiate into another cell type. Stem cell therapies for MS first emerged as promising candidates nearly two decades ago, but their success in the clinic has been limited, and public misunderstanding of these therapies threatens their legitimacy. However, there is no cure for MS, and very few treatment options exist for patients with advanced forms of the disease. ![]() Despite advancements in our understanding of the causes of multiple sclerosis (MS), a narrow selection of treatment options are available for the wide range of patient experiences.Īggressive treatment with immune-modifying drugs early in the disease course can mitigate the wear and tear of MS by reducing relapse and slowing down the body’s attack on brain cells. For others, it is a slow, smoldering progression. ![]() “They were leaner, had improved bone density and muscle strength and had a younger-looking immune system, among other benefits,” says Yadav.For some people, the attacks start as sudden and recurring. They also had lower hallmarks of ageing, such as reduced DNA damage and mitochondrial dysfunction. On average, these mice lived up to 12 per cent longer than those that weren’t given taurine. They therefore gave daily taurine supplements to 14-month-old mice, the equivalent age of a person between 45 and 50 years old. Next, the researchers wanted to see if reversing taurine’s decline could improve the animals’ health as they aged and potentially extend their lifespan. In a separate analysis of nearly 12,000 60-year-olds, higher taurine levels correlated with various markers of better health, including a lower prevalence of type 2 diabetes and reduced inflammation. Among the human participants, those aged around 65 had taurine levels that were more than 80 per cent lower than those of the study’s infant participants. To learn more, Vijay Yadav at Columbia University in New York and his colleagues measured taurine concentrations in the blood of mice, monkeys and humans, finding that its levels declined as they all aged.
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![]() In a prepackaged, portable, drive-thru culture, is it any wonder that they go for the microwave meal instead of baking from scratch? Candidates and handlers are fumbling their way through the untamed frontier territory of iPod Nation, a confusing geography where remix culture, sampling, shuffles and playlists rule the day and context is often absent. Hillary Rodham Clinton has used pieces of Tom Petty's "American Girl" and Mellencamp's "Small Town" to convey the basic imagery of their titles at a recent rally in a Pittsburgh suburb, her husband came on stage to the Police's "Every Little Thing She Does Is Magic." What the other lyrics might be didn't much matter. Often the songs are played in fragments as attempts to capture a mood rather than convey a message. His son's re-election theme in 2004, "Still the One," seems nice until you hear the verse, "sometimes I never want to see you again." Same with one of Barack Obama's 2008 choices, U2's "City of Blinding Lights," which features this line: "The more you see the less you know, the less you find out as you go." Bush's 1988 co-opting of Bobby McFerrin's ironic smile music - "Don't worry, be happy" - was about as astute as a helmeted Michael Dukakis poking his head out of a tank. ![]() ![]() We've seen how that turns out: Shouldn't presidential hopefuls bother to get a culture maven to idiot-proof song choices - or, at the least, print out a lyric sheet? Kennedy's time - songs crafted expressly for the candidates, among them "Tippecanoe and Tyler, Too," "Lincoln and Liberty" and the mercifully obscure "Get on a Raft with Taft." These days, the zeitgeist dictates that candidates invoke existing tunes. It's as if we're taking snapshots," says Oscar Brand, an 88-year-old folk musician and radio host who recorded an album of campaign music ranging from the eras of George Washington to Bill Clinton.īrand, though, focused mostly on what prevailed until roughly John F. "Interesting thing about campaign songs: They mirror the life of America. "Happy Days Are Here Again" may have worked for FDR in 1932, but ever since Reagan asserted in 1984 that Bruce Springsteen's "Born in the USA" was a patriotic paean, Democrats and Republicans alike have revealed tin ears as they try to set mood, convey message and show that they, too, are regular people attuned to the same mass entertainment as their fellow Americans.Īnd in doing so, they offer glimpses into the national temperament. For a generation, candidates who have tried to dip their toes into the pop-culture ocean have tended to fall in. ![]() This Viking 3 Series electric range has a glass-ceramic surface and detachable knobs for easy cleaning. oven capacity lets you prepare large meals. The Vari-Speed Dual Flow convection ensures maximum airflow for perfect cooking results, while the 4.7-cu. ![]() And we are in shock with how good this look !! Amazing finish it looks like a brand new stove !! Still missing a couple knobs we already ordered. Create delicious dinners with this 30-inch Viking 3 Series electric range. In addition, a wide variety of Viking range, ventilation and refrigeration products are available in Frost White to complete your personal vision and dream kitchen. We went with a matte black and gold color. This full palette of colors can be used for flooring, countertops, backsplashes and cabinetry. Then our first option was to take the parts to a car body shop and they recommended to take them to a powder coating company because there they bake the paint to make it heat resistant and extremely durable. 54' custom designed range hood color matched to the Viking blue range and accented with stainless steel an brass to co-ordinate with the range Inspiration for a contemporary kitchen remodel in Toronto. We spent a couple days just cleaning this nasty stove, that was probably the most difficult part of this project. Want to paint your stove but dont know what to use ? Here is what we did to update this old viking stove we got from FB marketplace for $500 Old Viking range makeover!! I am so exited about this project we did not know this was something possible to do but we decided to give it a try. Before Viking, home chefs had no options. ![]() Swords and Sandals III ends with the Starbound Gladiator being taken aboard the Automatons’ ship along with Bhaargle and an alien gladiator, where an Automaton explains that they have been selected to compete in the Galacticus Fantasticus – the greatest gladiator tournament in the galaxy.Swords and Sandals II ends with the Nameless setting sail from Doomtrek to Suul’s Gateway, drawn there by visions of Emperor Antares and a mysterious power deep beneath the mountains.You beating him allows him to return to human form and re-join his granddaughter. ![]() Sagan turned him into a Sagan Blob, keeping him was aware of his surroundings but incapable of influencing his own body. And I Must Scream: The (male) Evil Ninja made the mistake of trying to steal the wizard Sagan’s familiar, a rare rainbow-feathered owl.Ironhawk, the weapons salesman in Swords and Sandals V, lost his leg during the Siege of Braxis.A common death animation in the series involves the gladiator losing an arm or leg and being left to bleed to death on the sands.This was downplayed slightly in the Updated Re-release of the games, which included a link to the site’s lore section. All There in the Manual: The plot is fairly sparse in the first two games, with most of details about the setting, timeline, and characters being found on the official site.Alas, Poor Villain: “Villain” might be pushing it, but the protagonist admits to feeling no glory and faint sorrow at defeating The Yeti Project, and the narrative presents its death as a tragic, brutal end for a shy, reclusive creature that deserved better than to be forced to fight in Beastly Bloodsports.Others are completely fantastic, such as Arglaxx, Xanfar, and HeChaos. Others are overtly inspired by Greek Mythology and history, such as Platos, Spheracles, and Antares, or are simple descriptions of what the character is (like The Boneslinger, who’s a zombie cowboy). Some are relatively common, such as John, Anna, Sir Brian of May, and Louis. Aerith and Bob: The names of characters in the series are fairly diverse. ![]() ![]()
![]() When using the resize-pane command, the resize will be applied to the last pane that had focus. Which you can probably guess stands for down, up, left and right, the direction in which you want your pane to be resized. Now you’ll want to type in resize-pane in the prompt, followed by a hyphen - and either D, U, L, R. What this does is brings up a prompt at the bottom of your screen. tmux is an open source application that adds layers (or 'windows,' in tmux terminology) to your terminal window so that you can open more than one terminal in a single desktop window. To resize tmux panes, you’ll first want to hit your prefix - ctrl + b by default - and then the colon key. I recently discovered you can resize tmux panes. It lets you switch between several programs inside one terminal, detach and reattach them to a different terminal at will. Like this: windows: - CLIENTPOSTIONS: layout: main-vertical or main-horizontal panes: - cd /projects/bigbangservices/ - env PORT3002 rails server - bundle exec sidekiq -C config/sidekiq. But what if you don’t need certain panes to have so much real estate and focus? You just want a small pane to keep an eye on things. To use horizontal or vertical splits throughout the window, use main-horizontal or main-vertical. Tmuxinator lets you to set up your tmux sessions/windows/panes to run specific commands. Being able to have multiple panes in a single terminal window has definitely improved my workflow.īy default when creating panes, tmux will split the window up into 50% splits. There is many hooks to run commands at certain moments of the tmux run: when a project start, when it stops, etc. ![]() In this file, we specify how many windows and panes we want and their layouts. We create a new project, which opens up a YAML file. If you want to increase your productivity I would suggest learning more about tmux.I’ve been using tmux daily for about a month now and have been really enjoying it. tmuxinator is a tool to automate the creation of sessions with tmux. Tmuxinator is quite simple so there isn't much more to cover. ![]() ![]() In general it's recommended to keep it simple, especially if you are starting out with tmux, but if you want to try more complex sessions, make sure you use different leader keys for each layer!įor more info on using tmuxinator, the readme on their GitHub repo here contains documentation. The tmuxinator session is attached to netkit machine sessions, and one of the netkit machines (a) has its own tmux session open. To split a pane horizontally, press Ctrl+b and. sessionname: 3-panes windows: - windowname: dev window layout: main-vertical shellcommandbefore: - cd / panes: - shellcommand: - cd /var/log - ls -al. In theory you can nest multiple layers of sessions - for example here I have a tmux session on my host, with a pane SSHd into an Ubuntu VM, which has a tmux session started by tmuxinator. We can split a Tmux window either horizontally or vertically or both at once. If you use the same leader key in your tmux config, this will conflict and it is recommended to change it! If you haven't changed your tmux config, the leader key will be ctrl + b - so you don't need to worry about this. Using tmuxinator with netkit will give you at least two layers - as you have the main session - created with tmuxinator, which has panes that are attached to sessions which are created for the Netkit machines.īy default, the netkit machine sessions will use a leader key of ctrl + d. If youre a sysadmin, then you know youre going to need at least four open windows while you work on several systems at the same time. Then, open a new window with Ctrl+b+n, and execute tmux list-windows. To use it, start tmux and create panes with the things you want running in them. This can get very annoying, so it is recommended to use a different leader key for each layer of nesting. Inevitably, youre going to open a new terminal or a new tab so you can work in it while your first is busy compiling or converting or otherwise processing data. Tmuxinator is a launcher for tmux that allows you to specify and manage layouts and autostart applications with a YAML file. This means if you had the same leader key for an outer session and an inner session, you would have to hit the leader key twice in a row to send commands to the inner session. You need to remember when you nest sessions, that the outer session will intercept key presses first, and process them before they are passed to the next inner layer. This example would connect you to the pane for machine b when you run tmuxinator start abr. ![]() Personal Care Icons / Light / Previous 28 Open Personal Care MenuĪqua (purified water), camellia oleifera (camellia) seed oil, vitis vinifera (grape) seed oil, cetearyl olivate (plant), sorbitan olivate (plant), cetyl alcohol (plant), glycerin (plant), aloe barbadensis (aloe vera) leaf extract, sodium hyaluronate (tri-hyaluronan complex, plant), xanthan gum (natural polysaccharide), khaya senegalensis bark extract, oligopeptide-1 (peptide-3) (plant), maltodextrin, tocopherol (vitamin e) (plant), daucus carota sativa (carrot) root (plant), helianthus annuus (sunflower) seed oil, citrus sinensis (orange) peel oil expressed, sodium phytate (plant), wheat amino acids (plant), cananga odorata (ylang ylang) flower oil, viola odorata (violet) leaf extract, santalum spicata (sandalwood) wood oil, passiflora edulis (passionfruit) seed oil, mangifera indica (mango) seed butter, hippophae rhamnoides (sea buckthorn) fruit oil, illicium verum (star anise) fruit oil, myroxylon pereirae (peru balsam) oil, boswellia carterii (frankincense) oil, dehydroacetic acid, benzyl alcohol, limonene (plant), linalool (plant), benzyl benzoate (plant), benzyl salicylate (plant), farnesol (plant).Featured Categories Icons / Light / Previous 28 Open Featured Categories Menu.Body Moisturizers Icons / Light / Previous 28 Open Body Moisturizers Menu.Wellness Icons / Light / Previous 28 Open Wellness Menu.Hand Care Icons / Light / Previous 28 Open Hand Care Menu.Colour: VIEW ALL COLOURS VIEW FEWER COLOURS. 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![]() It has the S8 processor under its hood though - which is the same as the Watch Series 8 and Watch Ultra, and the Watch SE comes in GPS only and GPS and Cellular models. With the Apple Watch 4, the aluminum model is 30.1g for the. It misses out on the Always-On Display from the Series 8 though, as well as blood oxygen monitoring, body temperature sensor and the electrical heart rate sensor for taking an ECG, plus there aren't as many finish options as the Series 8. The Stainless Steel Apple Watch is 42.4 grams in 38mm and 52.8 grams in 42mm thanks to the heavier Stainless Steel. It has plenty of features, including waterproofing, built-in GPS, an always-on altimeter, a built-in compass, fall detection and Car Crash Detection. WINGLE Stainless Steel Band for Apple Watch Ultra Band 49mm 45mm 44mm 42mm, Solid Metal Strap with Folding Clasp for Apple Watch Series 8 7 SE 6 5 4 for Men iWatch (Silver, 49mm 45mm 44mm 42mm) 19 3648 Prime 5. The Apple Watch SE is the entry-level model, offering the same design as the older Series 6 with a larger display, along with a number of its features, but not as streamlined a design as the Series 8 in terms of display. Hassle-Free Exchanges & Returns for 30 Days. ![]()
She heads to Jerry’s book signing, but Nora is there first. Successfully guilt-tripped, Jean sheepishly heads off with the list. Jean Davis: errand runner extraordinaire since 1955! It’s the least she can do if she’s planning to leave Nora after all those years of dedicated service, after all. Nora is dismayed and, knowing the lovebirds have planned a date for later, tearfully demands Jean instead run an extensive list of errands. Jean subsequently announces that she and Jerry are to be married. Nora, however, isn’t taking the bait, and Jerry quickly exits stage left to a book signing. He’s demanded quite a sum from her to prevent him blabbing to the studio bosses that she defrauded them to the tune of $2 million dollars years before. There she finds long-time assistant Jean Davis cooing sweet nothings to gossip journalist Jerry Parks – a man whom Nora clearly has precious little love for. An explosive start it may be, but this is just an action-packed scene from a forthcoming TV movie starring former Silver Screen Queen, Nora Chandler.įilming wrapped up, Nora heads home to her ‘cottage’ – a half-acre dwelling slap-bang in the middle of the Universal Studios lot. ![]() ![]() Is this the quickest Columbo killing since Season 1’s Suitable for Framing? Not quite. Written by: Jackson Gillis Episode synopsis: Columbo Requiem for a Falling StarĪ dark-clad female enters a bathroom and fires a gun through a screen door at a silhouetted form, which slumps to the ground. But is Requiem for a Falling Star a comeback of epic proportions, or a straight to VHS bargain bucket affair? Let’s see… He was also back in LA and hanging out with Tinseltown legend Nora Chandler after boobing around in London in his last outing. More important than all that, though, Janumarked the return of Columbo to screens after a two-month winter break. Against the backdrop of the oil crisis and Vietnam war, Richard Nixon was sworn in for a second (and short) term of office, while the Miami Dolphins won Superbowl VII to complete the NFL’s first ever ‘Perfect Season’. January 1973 was an intriguing month in US history. Each show has a recommended age limit for those attending.įilm Series consists of "classic movies, hidden gems, and contemporary productions." While they are not performances they are productions related to puppetry. The New Directions Series are known for being more thought-provoking and visually appealing. The Center for Puppetry Arts also has the New Directions Series which features teen and adult-oriented shows by Atlanta artists and visiting companies. Included with many Family Performances is a Create-A-Puppet workshop that relates to the show. National traveling puppetry troupes set up shop at the center during SummerFest and perform a variety of works for families. Family Performances are made up of shows that the center's company creates/performs, as well as other artists from around the world. Past shows have included an adaptation of The Shoemaker & The Elves set in 1940s Manhattan, Jon Ludwig's Dinosaurs, and The Ghastly Dreadfuls' Compendium of Graveyard Tales and Other Curiosities, a Halloween-themed variety show. Performances Įach year the Center for Puppetry Arts presents the Family Series, a collection of adapted classic stories and new works performed in a variety of puppetry styles by the center company. The wing, which is a part of the center's new building, opened November 14, 2015. The new wing also includes films, sketches, and other materials from the Jim Henson Company archives. On July 25, 2007, the center announced the opening of a new Jim Henson Wing, which houses anywhere from 500 to 700 retired Muppets, including those from Fraggle Rock, The Muppet Show, and Sesame Street. The Center reaches the community through its focus on core programming: performance, museum and education. Since its inception, the center has worked to serve the diverse populations of Atlanta, the state of Georgia, and the country at large. That first season, the center mounted an exhibition of puppets, presented shows for adults and families, and hosted community-based workshops and activities that continue to this day. In 1978, Anthony found a permanent home in the former Spring Street Elementary School and the center was born. They created a successful touring company that traveled around the southeast and presented several seasons at Atlanta's Woodruff Arts Center. Vince's vision was to create a center that would promote puppetry and become a vital part of the community. Together with Mitchell Edmonds, with whom he'd worked at Nicolo, they decided to move to Atlanta to create their own company - The Vagabond Marionettes. By 1966, he was ready for a smaller community where he could be an active partner and make a difference. The Center for Puppetry Arts opened to the public on September 23, 1978, when Kermit the Frog and his creator Jim Henson cut the ceremonial ribbon.Ī young puppeteer from Florida, Vincent Anthony, began touring with Nicolo Marionettes under the tutelage of Nicholas Coppola-based out of New York City. It was founded in 1978 by Vincent Anthony. ![]() The center is located in Midtown, the city's arts district. It is one of the few puppet museums in the world. ![]() The center focuses on three areas: performance, education and museum. The Center for Puppetry Arts, located in Atlanta, is the United States' largest organization dedicated to the art form of puppetry. ![]() " The Last of the Starks": Tyrion approaches the walls of King's Landing and asks Cersei to surrender Missandei is executed by Ser Gregor Daenerys leaves in anger. " The Last of the Starks": The dead are mourned and the funeral pyres are lit. A rendition of "The Night King" with choirs. Contains Melisandre's theme ("The Red Woman") and hints of the main theme. ![]() Ser Jorah dies in Daenerys's arms Melisandre walks into the snow and dies. " The Long Night": The dead are defeated. Sansa and Tyrion share a tender moment Jon is attacked by Viserion the Night King kills Theon and approaches Bran. " The Long Night": Climax of the Battle of Winterfell. " The Long Night": The Night King raises the dead of Winterfell Ser Jorah and Daenerys fight against the wights. Contains the White Walkers ("Against All Odds", "White Walkers", and "The Army of the Dead") and Arya melodies ("Valar Morghulis" and "Needle"). " The Long Night": Arya is fighting the army of the dead Lord Beric Dondarrion urges the Hound to fight Lyanna Mormont dies killing a wight giant. Contains the White Walkers ("Against All Odds", "White Walkers", and "The Army of the Dead") and Targaryen melodies ("Love in the Eyes", "Dracarys", "Breaker of Chains", and "Dance of Dragons"). Contains Melisandre's theme ("The Red Woman"). " The Long Night": Ser Davos realizes Daenerys can't see the signal to set the trench on fire Melisandre lights the trench. Contains Melisandre's theme ("The Red Woman") and the main theme. " The Long Night": At the beginning of the battle, Melisandre lights the swords and the Dothraki charge. " A Knight of the Seven Kingdoms": Jaime knights Brienne. " A Knight of the Seven Kingdoms": An a cappella version of the song is sung by Podrick. ![]() " Winterfell": Samwell tells Jon that he is an heir to the Iron Throne. Contains the Daenerys and Jon Snow theme ("Truth"). " Winterfell": Jon rides Rhaegal for the first time, and Daenerys rides Drogon. ![]() " The Last of the Starks": The melody appears when Daenerys rides Drogon besides Rhaegal in Dragonstone, before Euron Greyjoy strikes Rhaegal. Contains the House Baratheon theme ("The King's Arrival"), the dragon theme ("Breaker of Chains"), and the House Stark theme ("Goodbye Brother"). Jon and Daenerys arrive in Winterfell with Daenerys's armies. " The Rains of Castamere" (with Serj Tankian) We always treated the music as another character in the show." Track listing It definitely misled the audience because of what they knew from 'Light of the Seven', back in season six. ĭjawadi says of his track "The Night King": "When I talked to Miguel, the director, and when David and came to my studio and we started working on this episode, we all agreed that it had to be a piano piece again, just like ' Light of the Seven'. "It's been such an honor to be a part of this incredible show for the past eight years", said Ramin Djawadi. Ramin Djawadi received his seventh Primetime Emmy Award nomination, for Outstanding Music Composition for a Series (Original Dramatic Score), for the season's third episode, " The Long Night" and then won the award, making two consecutive wins for Djawadi. What the heck happened in Westeros back in Game of Thrones season one? In the first season we first see Daenerys Targareyen's rise from slave to queen, Ned Stark's discovery of a disturbing Lannister secret, the death of a King, the awesomeness of Tyrion, the kickass gal that is Arya Stark, and the first signs of a winter which threatens to destroy everything.Ĭatch up with the Lannisters, Starks, Baratheons, Tullys, Dothrakis, and men of the Night's Watch in the GOT recap below and don't forget to check out these recaps of Game of Thrones season two and Game of Thrones season three.The soundtrack album of the eighth season of HBO series Game of Thrones, titled Game of Thrones: Season 8, was released digitally on May 19, 2019, a double CD was released July 19, 2019, and was released on vinyl later in the year. The Game of Thrones first season aired on HBO in 2011, and with all the plot twists and new characters GoT throws at viewers, it's always good to refresh your memory with a quick summary, and that's exactly what you'll find in this Game of Thrones season 1 recap. Game of Thrones season 1 introduced fantasy and epic fans to the cutthroat and brutal world of Westeros and the lengths to which people are willing to go to sit on the coveted Iron Throne. |
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